Scientific Program

Day 1 :

  • Keynote Forum

Session Introduction

A. Pavlenko

Kiev Polytechnical Institute,Ukraine

Title: Possible ways to neutralize biopathogenic radiation.
Speaker
Biography:

A. Pavlenko has completed his PhD at the age of 37 years from Sevastopol Polytechnical Institute. He is the director of “Spinor International”, Head of the Laboratory of the   Electron Devices chair at Kiev Polytechnical Institute. i has published more than 50 papers in reputed journals and has been serving as Member of the editorial boards of a scientific periodical: Ukrainian Journal   Physical vacuum and Nature.

 

 

Abstract:

Techno pathogenic effect - a set of factors and processes that have any kind of negative effect or impact on living organisms resulting from scientific and technological progress of mankind.This is a summary of ideas and methods for protecting the public from the negative impact of electronic technology. While conducting research, the author tried to clearly define the prevailing negative impact on living of torsion fields (TF) in comparison with electromagnetic radiation. Electromagnetic fields warm the tissues of a person using all sorts of gadgets, while torsion fields affect the gene level. Much attention is paid to the technology of protection from  torsion fields.American biologists drew attention to this phenomenon, calling such radiation "nonclassical electromagnetic radiation". The specific absorption rate (SAR) is considered as an official standard for measuring the effects of electromagnetic radiation (EMR) from mobile phones on human brains.However, the biologists do not consider SAR measurements as an accurate representation of mobile phone EMR effects on the human brain in real life. As an alternative of SAR the increasing number of scientists uses the biological systems for evaluation of harmful effects of mobile phone EMR. In the above-mentioned works the positive moment is a reference to "non-classical" electromagnetic fields though their physical nature has not been disclosed. In our opinion the "non-classical" electromagnetic fields are torsion fieldsWe need to convey to people the truth about the impact of electronic technology on the living.

 

Speaker
Biography:

Alireza Khanteymoori is an assistant professor in department of computer engineering at University of Zanjan. He is also head of Machine Learning and Bioinformatics Lab (MLBL). His research interests include Bioinformatics, Machine Learning, Biological Networks and Probabilistic Graphical Models.

 

Abstract:

The reconstruction of the topology of gene regulatory networks (GRNs) using high throughput genomic data such as microarray gene expression data is an important problem in systems biology. The main challenge in gene expression data is the high number of genes and low number of samples; also, the data are often impregnated with noise. In this speech, in dealing with the noisy data, Kalman filter based method that has the ability to use prior knowledge on learning the network will be presented. 

 

Speaker
Biography:

Head of Laboratory of bio mechanical systems research in Mechanical Engineering Research Institute of the Russian Academy of Sciences; Chief researcher of the Center of interdisciplinary researches of musical creativity of the Tchaikovsky Moscow State Conservatory; Editor-in-Chief of International Journal of Mathematical Sciences and Computing. Russian organizer of the series of annual Russian-Chinese conferences Artificial Intelligence, Medical Engineering, Education. Co-organizer of many conferences in different countries. He is the author of 7 books and more than 200 other works. He graduated from the Moscow Physical-Technical Institute in the Department of Physics of Living Systems.

 

Abstract:

Hidden symmetries in long sequences of oligonucleotides of single stranded DNA from their representative set are described. These symmetries are an addition to symmetries described by the second Chargaff’s parity rule (%A ≅ %T and %G ≅ %C). These new symmetries and their rules concern collective probabilities of oligonucleotides from special tetra-alphabetical sets in long DNA-texts including all chromosomes of human and some model organisms [1]. These rules of tetra-alphabetical probabilities are considered as candidacies for the role of universal rules of long DNA-sequences. On the basis of the known quantum-mechanic statement that quantum state of a multi-component system is defined by the tensor product of quantum states of its subsystems, a quantum-information model of genetic symmetries of these collective probabilities was proposed. In this model, nitrogenous bases C, T, G, A of DNA were represented as computational basis states of 2-qubit quantum systems [1]. The biological meaning of the new quantum-information symmetries of long DNA-texts can be connected with the common ability of organisms to grow on the basis of incorporation into their body of new molecules of nutrients becoming new quantum-mechanic subsystems of the united quantummechanical organism.

 

Speaker
Biography:

Dr. Francis Amirtharaj serves as an Assistant Professor/Research Scientist at the Thumbay Research Institute for Precision Medicine, Gulf Medical University, Ajman, UAE since 2016. He earned his Ph.D. from the Madras University/CCMB and He has conducted research at Centre for Cellular and Molecular Biology, Hyderabad, India as a post-doctoral fellow.  He is expertise in various molecular biology techniques, such as next-generation sequencing (NGS), Sanger sequencing, real-time PCR etc. His current research interest to study the influence of p53 and its inactivation mutations in various cancer. He has ample teaching experience in Molecular Biology.

 

Abstract:

Dysferlin (DYSF) is a 237kDa transmembrane protein found in sarcolemma, known to facilitate membrane repair in skeletal muscles, muscle differentiation, membrane fusion, etc. The deficiency of DYSF due to mutations is one of the cause for Limb-Girdle Muscular Dystrophy 2B (LGMD2B), Miyoshi Myopathy (MM) and a distal anterior compartment myopathy (DMAT), which are collectively named dysferlinopathy. DYSF gene is located on chromosome 2 (2p13), encompasses 55 coding exons and spans 150 kb of genomic DNA. To evaluate the role of DYSF gene mutation(s) in Indian dysferlinopathies, we have performed both genetic and immunological analyses in 66 clinically defined cases. Western blot analysis of muscle specimens confirmed that all of them had dysferlin deficiency. All the 55 exons of DYSF were sequenced to find mutation(s) that are associated with dysferlinopathies. Sequence analysis of the dysferlin gene in these patients revealed a total of 84 variants. Of these, 51 were novel mutations that include 6 missense mutations; 6 silent mutations; 1 termination mutation; 3 frameshift mutations; 7 splice site variations; and 28 in intronic region and 33 previously reported mutations (5 missense; 7 silent; 1 termination mutation; 5 splice site; and 15 intronic region). This is the first extensive study of DYSF mutations in Indian dysferlinopathy samples. We have identified several novel and functionally significant mutation, which can be used as diagnostic markers.

 

  • Sequence Analysis | Gene Expression | Simulation and Modelling | Health Informatics |Biomedical Informatics

Session Introduction

Syed Shakeel Shah

University of Gujrat ,Pakistan

Title: DETECTION OF THE DENGUE VIRUS FROM AEDES AND CULEX BY PCR
Speaker
Biography:

Abstract:

Since the first reported outbreak of dengue hemorrhagic fever in Pakistan, several mini outbreaks have been observed in the country. In Pakistan, Serotype 2 (DEN-2) is documented since 1994 and is the major circulating serotype in the region. Dengue virus serotype 3 (DEN-3) was first reported in Karachi during 2005 outbreak. Dengue virus has now become a serious threat to humans especially in developing countries. As yet, no vaccine and proper treatment is available for dengue virus, so control of vector is the only option left to control dengue infection. Aedes mosquitoes are well known vector for this virus but some studies show that dengue virus can also survive in Culex mosquitoes. So, we have conducted a study to compare the vectorial role of Aedes and Culex in Lahore by using molecular techniques such as PCR and nucleotide sequencing of the C-prM gene junction of Dengue virus.A total of 1,110 adult resting mosquitoes were collected from selected localities of Urban Lahore. Of collected Aedes (n=498) and Culex (n=612) each were divided into 45 pools separately. After molecular analysis, 6 pools of Aedes (13.33%) and 9 pools of Culex (20%) were found positive for dengue virus. Interestingly, in all positive pools only serotype-2 of dengue virus was detected.We have found only serotype-2 of dengue virus in our study but other studies also report the presence of serotype-3. The occurrence of serotype-1 and serotype-4 in Pakistan, till now, is not reported. The presence of dengue virus in Culex in such a high per cent is alarming 


 

Speaker
Biography:

Segundo Mesa Castillo. As Specialist in Neurology, he worked for 10 years in the Institute of Neurology of Havana, Cuba.  He has worked in Electron Microscopic Studies on Schizophrenia for 32 years. He was awarded with the International Price of the Stanley Foundation Award Program and for the Professional Committee to work as a fellowship position in the Laboratory of the Central Nervous System Studies, National Institute of Neurological Diseases and Stroke under Dr. Joseph Gibbs for a period of 6 months, National Institute of Health, Bethesda, Maryland, Washington D.C. USA, June 5, 1990. At present he is member of the Scientific Board of the Psychiatric Hospital of Havana and give lectures to residents in psychiatry.

 

Abstract:

There is increasing evidences that favor the prenatal beginning of schizophrenia. These evidences point toward intra-uterine environmental factors that act specifically during the second pregnancy trimester producing a direct damage of the brain of the fetus [1]. The current available technology doesn't allow observing what is happening at cellular level since the human brain is not exposed  to a direct analysis in that stage of the life in subjects at high risk of developing schizophrenia. Methods. In 1977 we began a direct electron microscopic research of the brain of fetuses at high risk from schizophrenic mothers in order to finding differences at cellular level in relation to controls. Results. In these studies we have observed within the nuclei of neurons the presence of complete and incomplete viral particles that reacted in positive form with antibodies to herpes simplex hominis type I [HSV1] virus, and mitochondria alterations [2]. Conclusion. The importance of these findings can have practical applications in the prevention of the illness keeping in mind its direct relation to the aetiology and physiopathology of schizophrenia. A study of the gametes or the amniotic fluid cells in women at risk of having a schizophrenic offspring is considered. Of being observed the same alterations that those observed previously in the cells of the brain of the studied foetuses, it would intend to these women in risk of having a schizophrenia descendant, previous information of the results, the voluntary medical interruption of the pregnancy or an early anti HSV1 viral treatment as preventive measure of the later development of the illness.

 

Speaker
Biography:

Abstract:

Cytotoxic lymphocytes (CL) eliminate virus infected and tumour cells by initiating target cell apoptosis through two pathways: ligation of cell surface death receptors and the granule exocytosis pathway. The granule exocytosis pathway involves secretion of cytotoxic granules containing perforin and granzymes into target cells, thereby initiating apoptotic pathways. Perforin is a pore forming protein that utilizes a poorly understood mechanism to efficiently deliver granzymes, a family of serine proteases synthesized by CL, into the target cell cytoplasm.In humans, there are five Granzyme genes (GzmA, GzmB, GzmH, GzmK, GzmM) located at three different chromosomal loci. Based on their specificities theses serine proteases can be grouped into tryptases (GzmA and GzmK), aspases (GzmB) and chymases (GzmM and GzmH). These different granzymes perform intra– and extracellular functions. Three intracellular roles, dependent on perforin-mediated delivery into target cells, have been described: cytotoxicity, accessory functions and cytokine signalling. Extracellular functions, independent of perforin, have been reported for some granzymes and involve cleavage of extracellular matrix; possibly to facilitate immune cells migration. Although less data is available for these proteases, however the over-expression of these genes in certain disease conditions like autoimmune diseases has made it a subject of interest for designing potential inhibitors to stop their activity, as when they are synthesized in excess, becomes lethal to normal cells in a human body. This presentation will highlight the significance of these proteases and their possible involvement in various disease conditions.

 

Speaker
Biography:

Abstract:

Current technology and social media play a big role in modern life. Also, people are getting more involved with their health information. Where medical advices should meet social legal requirement with the respect to patient rights and needs. Current healthcare systems are overloaded with increasing flow of patients. In case of chronic patients or in time of seasonal infections or operating simple surgical procedures, the doctors and the assistant team can be faced with huge number of patients and they have to spend log time in clinic to serve them.We provide a professional Medical Social Media, our network doctors have their own cloud clinic an advanced tele-medicine system based on lightweight set of medical devices connected to a mobile based application to connect the patient and doctor or doctor to hospital were all medical measures are available to the remote doctor for efficient medical support. A layout of social media platforms and its daily use will help to change the lifestyle of the patient and that will reflect on the public health.  Our solution is more than mobile based appointment and Video/Audio communication system. It collects patient data from the devices to the mobile App and from that to our cloud-based IT system. Integration of Telemedicine Hardware and Software Components will definitely lead to a better telemedicine practice when the data can be shared with the doctor in real time at any time. The system powered by artificial intelligent to analyzes the medical data (bio-test, visits reports, genetic testing), activities and raises certain alarms when certain abnormalities accrue. We believe our application will change the way medicine is practiced as well as adding a great trustful resource of getting medical advices or real time consultations. It will bring advances in IT, mobile computing, body sensors, and cloud computing to the medical practice and will create a new form of electronic health records and more effective deliverance of healthcare services. All this is integrated in a professional social media platform, which will create an impact on the public health after the remarkable lifestyle change of the society with an equal opportunity of treatment and healthcare to everyone with an Internet connection. Thus, easy healthcare access will help people to manage both illness and health.